Optimization of Benzoisothiazole dioxide inhibitory activity of the NS5B polymerase of HCV genotype 4 using ligand-steered homological modeling, reaction-driven scaffold-hopping and Enovo workflow

Infection caused by hepatitis C virus (HCV) is a significant world health problem for which novel therapies are in urgent demand. The virus is highly prevalent in the Middle East and Africa particularly Egypt with more than 90% of infections due to genotype 4. Nonstructural (NS5B) viral proteins hav...

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Main Authors: Mahmoud, Amr Hamed, Mohamed Abouzid, Khaled Abouzid, El Ella, Dalal Abd El Rahman Abou, Hamid Ismail, Mohamed Abdel
Formato: Artigo
Idioma:Inglês
Publicado em: Biomedical Informatics 2011
Assuntos:
Hypothesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280486/
https://ncbi.nlm.nih.gov/pubmed/22355232
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