Identification and Characterization of a Novel Calcium-Activated Apyrase from Cryptosporidium Parasites and Its Potential Role in Pathogenesis

Herein, we report the biochemical and functional characterization of a novel Ca(2+)-activated nucleoside diphosphatase (apyrase), CApy, of the intracellular gut pathogen Cryptosporidium. The purified recombinant CApy protein displayed activity, substrate specificity and calcium dependency strikingly...

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Autors principals: Manque, Patricio A., Woehlbier, Ute, Lara, Ana M., Tenjo, Fernando, Alves, João M., Buck, Gregory A.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280346/
https://ncbi.nlm.nih.gov/pubmed/22363541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031030
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