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Depletion of the actin bundling protein SM22/transgelin increases actin dynamics and enhances the tumourigenic phenotypes of cells

BACKGROUND: SM22 has long been studied as an actin-associated protein. Interestingly, levels of SM22 are often reduced in tumour cell lines, while they are increased during senescence possibly indicating a role for SM22 in cell fate decisions via its interaction with actin. In this study we aimed to...

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Autors principals: Thompson, Oliver, Moghraby, Jeelan S, Ayscough, Kathryn R, Winder, Steve J
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3280177/
https://ncbi.nlm.nih.gov/pubmed/22257561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-13-1
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