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Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs
p53 binds as a tetramer to DNA targets consisting of two decameric half-sites separated by a variable spacer. Here we present high-resolution crystal structures of complexes between p53 core-domain tetramers and DNA targets consisting of contiguous half-sites. In contrast to previously reported p53-...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3280089/ https://ncbi.nlm.nih.gov/pubmed/20364130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1800 |
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