A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α–positive tumors

Deregulated accumulation of hypoxia-inducible factor-1α (HIF-1α) is a hallmark of many solid tumors. Directly targeting HIF-1α for therapeutics is challenging. Our finding that HIF-1α regulates secretion of heat shock protein-90α (Hsp90α) for cell migration raises the exciting possibility that targe...

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Autori principali: Sahu, Divya, Zhao, Zhengwei, Tsen, Fred, Cheng, Chieh-Fang, Park, Ryan, Situ, Alan J., Dai, Jinyao, Eginli, Ariana, Shams, Sharmineh, Chen, Mei, Ulmer, Tobias S., Conti, Peter, Woodley, David T., Li, Wei
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3279389/
https://ncbi.nlm.nih.gov/pubmed/22190738
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E11-06-0575
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