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Nontransgenic Hyperexpression of a Complement Regulator in Donor Kidney Modulates Transplant Ischemia/Reperfusion Damage, Acute Rejection, and Chronic Nephropathy

Complement activation during ischemia and reperfusion contributes to the development of tissue injury with severe negative impact on outcomes in transplantation. To counter the effect of complement, we present a strategy to deliver a novel complement regulator stabilized on cell surfaces within dono...

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Detalhes bibliográficos
Main Authors: Pratt, Julian R., Jones, Miriam E., Dong, Jun, Zhou, Wuding, Chowdhury, Paramit, Smith, Richard A. G., Sacks, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278791/
https://ncbi.nlm.nih.gov/pubmed/14507653
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