The Duration of Nicotine Withdrawal-Associated Deficits in Contextual Fear Conditioning Parallels Changes in Hippocampal High Affinity Nicotinic Acetylcholine Receptor Upregulation

A predominant symptom of nicotine withdrawal is cognitive deficits, yet understanding of the neural basis for these deficits is limited. Withdrawal from chronic nicotine disrupts contextual learning in mice and this deficit is mediated by direct effects of nicotine in the hippocampus. Chronic nicoti...

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Autors principals: Gould, Thomas J., Portugal, George S., André, Jessica M., Tadman, Matthew P., Marks, Michael J., Kenney, Justin W., Yildirim, Emre, Adoff, Michael
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278577/
https://ncbi.nlm.nih.gov/pubmed/22285742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2012.01.003
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