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DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease

Alzheimer's disease (AD) is an incurable and progressive neurodegenerative senile disorder associated with the brain accumulation of Aβ plaques. Although vaccines that reduce Aβ plaques can control AD, the rationale for their use at the onset of the disease remains debatable. Old humans and mic...

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Detalhes bibliográficos
Main Authors: Olkhanud, Purevdorj B., Mughal, Mohammed, Ayukawa, Koichi, Malchinkhuu, Enkhzol, Bodogai, Monica, Feldman, Neil, Rothman, Sarah, Lee, John, Chigurupati, Srinivasulu, Okun, Eitan, Nagashima, Kunio, Mattson, Mark P., Biragyn, Arya
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278568/
https://ncbi.nlm.nih.gov/pubmed/22248819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2011.12.136
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