Cell-to-Cell Transfer of HIV-1 via Virological Synapses Leads to Endosomal Virion Maturation that Activates Viral Membrane Fusion

HIV-1 can infect T cells by cell-free virus or by direct virion transfer between cells through cell contact-induced structures called virological synapses (VS). During VS-mediated infection, virions accumulate within target cell endosomes. We show that after crossing the VS, the transferred virus un...

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Bibliografiske detaljer
Main Authors: Dale, Benjamin M., McNerney, Gregory P., Thompson, Deanna L., Hubner, Wolfgang, de los Reyes, Kevin, Chuang, Frank Y.S., Huser, Thomas, Chen, Benjamin K.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3278276/
https://ncbi.nlm.nih.gov/pubmed/22177560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.10.015
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