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Axonal damage in the making: Neurofilament phosphorylation, proton mobility and magnetisation transfer in multiple sclerosis normal appearing white matter()

AIMS: Multiple sclerosis (MS) leaves a signature on the phosphorylation and thus proton binding capacity of axonal neurofilament (Nf) proteins. The proton binding capacity in a tissue is the major determinant for exchange between bound and free protons and thus the magnetisation transfer ratio (MTR)...

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Main Authors: Petzold, A., Tozer, D.J., Schmierer, K.
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277890/
https://ncbi.nlm.nih.gov/pubmed/21958956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2011.09.011
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