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The Use of Occupation Isoboles for Analysis of a Response Mediated by Two Receptors: M(2) and M(3) Muscarinic Receptor Subtype-Induced Mouse Stomach Contractions
Smooth muscle contains multiple muscarinic receptor subtypes, including M(2) and M(3). M(2) receptors outnumber M(3) receptors. Based on the potency of subtype selective anticholinergics, contraction is mediated by the M(3) subtype. However, results from knockout (KO) mice show that the M(2) recepto...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3277794/ https://ncbi.nlm.nih.gov/pubmed/18339971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.137018 |
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