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Enhanced Sensitivity for High Spatial Resolution Lipid Analysis by Negative Ion Mode MALDI Imaging Mass Spectrometry

We have achieved enhanced lipid imaging to a ~10 μm spatial resolution using negative ion mode matrix assisted laser desorption ionization (MALDI) imaging mass spectrometry, sublimation of 2,5-dihydroxybenzoic acid as the MALDI matrix and a sample preparation protocol that uses aqueous washes. We re...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Angel, Peggi M., Spraggins, Jeffrey M., Baldwin, H. Scott, Caprioli, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277660/
https://ncbi.nlm.nih.gov/pubmed/22243218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ac202383m
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