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GeoFold: Topology-based protein unfolding pathways capture the effects of engineered disulfides on kinetic stability

Protein unfolding is modeled as an ensemble of pathways, where each step in each pathway is the addition of one topologically possible conformational degree of freedom. Starting with a known protein structure, GeoFold hierarchically partitions (cuts) the native structure into substructures using rev...

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Main Authors: Ramakrishnan, Vibin, Srinivasan, Sai Praveen, Salem, Saeed M, Matthews, Suzanne J, Colón, Wilfredo, Zaki, Mohammed, Bystroff, Christopher
格式: Artigo
語言:Inglês
出版: 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277656/
https://ncbi.nlm.nih.gov/pubmed/22189917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.23249
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