Toll-like receptor 3 signaling converts tumor-supporting myeloid cells to tumoricidal effectors

Smoldering inflammation often increases the risk of progression for malignant tumors and simultaneously matures myeloid dendritic cells (mDCs) for cell-mediated immunity. PolyI:C, a dsRNA analog, is reported to induce inflammation and potent antitumor immune responses via the Toll-like receptor 3/To...

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Hlavní autoři: Shime, Hiroaki, Matsumoto, Misako, Oshiumi, Hiroyuki, Tanaka, Shinya, Nakane, Akio, Iwakura, Yoichiro, Tahara, Hideaki, Inoue, Norimitsu, Seya, Tsukasa
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277567/
https://ncbi.nlm.nih.gov/pubmed/22308357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113099109
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