Histone deacetylases mediate the silencing of miR-15a, miR-16, and miR-29b in chronic lymphocytic leukemia

Chronic lymphocytic leukemia (CLL) demonstrates a global down-regulation of miR-15a and miR-16 and a selective silencing of the related miR-29b in aggressive disease. Deletions in chromosome 13 [del(13q14)] partially account for the loss of expression of miR-15a and miR-16, but the mechanisms by whi...

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Bibliografische gegevens
Hoofdauteurs: Sampath, Deepa, Liu, Chaomei, Vasan, Karthik, Sulda, Melanie, Puduvalli, Vinay K., Wierda, William G., Keating, Michael J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2012
Onderwerpen:
Lymphoid Neoplasia
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277352/
https://ncbi.nlm.nih.gov/pubmed/22096249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-05-351510
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