Construction of an Oncolytic Herpes Simplex Virus That Precisely Targets Hepatocellular Carcinoma Cells

Selective replication in tumor cells is a highly desirable feature for oncolytic viruses. Recent studies have shown that microRNAs (miRNAs) play important roles in controlling gene expression, and that certain tissue-specific miRNAs are frequently downregulated in malignant cells. miR-122 is a liver...

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Main Authors: Fu, Xinping, Rivera, Armando, Tao, Lihua, De Geest, Bart, Zhang, Xiaoliu
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2012
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277243/
https://ncbi.nlm.nih.gov/pubmed/22146341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.265
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