Brush border Myosin Ia has tumor suppressor activity in the intestine

The loss of the epithelial architecture and cell polarity/differentiation is known to be important during the tumorigenic process. Here we demonstrate that the brush border protein Myosin Ia (MYO1A) is important for polarization and differentiation of colon cancer cells and is frequently inactivated...

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Main Authors: Mazzolini, Rocco, Dopeso, Higinio, Mateo-Lozano, Silvia, Chang, Wakam, Rodrigues, Paulo, Bazzocco, Sarah, Alazzouzi, Hafid, Landolfi, Stefania, Hernández-Losa, Javier, Andretta, Elena, Alhopuro, Pia, Espín, Eloy, Armengol, Manel, Tabernero, Josep, Ramón y Cajal, Santiago, Kloor, Matthias, Gebert, Johannes, Mariadason, John M., Schwartz, Simo, Aaltonen, Lauri A., Mooseker, Mark S., Arango, Diego
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3277176/
https://ncbi.nlm.nih.gov/pubmed/22307608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108411109
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