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Age-Related Somatic Structural Changes in the Nuclear Genome of Human Blood Cells

Structural variations are among the most frequent interindividual genetic differences in the human genome. The frequency and distribution of de novo somatic structural variants in normal cells is, however, poorly explored. Using age-stratified cohorts of 318 monozygotic (MZ) twins and 296 single-bor...

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Detalhes bibliográficos
Main Authors: Forsberg, Lars A., Rasi, Chiara, Razzaghian, Hamid R., Pakalapati, Geeta, Waite, Lindsay, Thilbeault, Krista Stanton, Ronowicz, Anna, Wineinger, Nathan E., Tiwari, Hemant K., Boomsma, Dorret, Westerman, Maxwell P., Harris, Jennifer R., Lyle, Robert, Essand, Magnus, Eriksson, Fredrik, Assimes, Themistocles L., Iribarren, Carlos, Strachan, Eric, O'Hanlon, Terrance P., Rider, Lisa G., Miller, Frederick W., Giedraitis, Vilmantas, Lannfelt, Lars, Ingelsson, Martin, Piotrowski, Arkadiusz, Pedersen, Nancy L., Absher, Devin, Dumanski, Jan P.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276669/
https://ncbi.nlm.nih.gov/pubmed/22305530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.12.009
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