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Novel Transcript Truncating Function of Rap1p Revealed by Synthetic Codon-Optimized Ty1 Retrotransposon

Extensive mutagenesis via massive recoding of retrotransposon Ty1 produced a synthetic codon-optimized retrotransposon (CO-Ty1). CO-Ty1 is defective for retrotransposition, suggesting a sequence capable of down-regulating retrotransposition. We mapped this sequence to a critical ∼20-bp region within...

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Detalhes bibliográficos
Main Authors: Yarrington, Robert M., Richardson, Sarah M., Lisa Huang, Cheng Ran, Boeke, Jef D.
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276619/
https://ncbi.nlm.nih.gov/pubmed/22135353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.111.136648
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