Reduced COX-2 Expression in Aged Mice Is Associated With Impaired Fracture Healing

The cellular and molecular events responsible for reduced fracture healing with aging are unknown. Cyclooxygenase 2 (COX-2), the inducible regulator of prostaglandin E(2) (PGE(2)) synthesis, is critical for normal bone repair. A femoral fracture repair model was used in mice at either 7–9 or 52–56 w...

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Main Authors: Naik, Amish A, Xie, Chao, Zuscik, Michael J, Kingsley, Paul, Schwarz, Edward M, Awad, Hani, Guldberg, Robert, Drissi, Hicham, Puzas, J Edward, Boyce, Brendan, Zhang, Xinping, O'Keefe, Regis J
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR) 2009
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Research-Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276605/
https://ncbi.nlm.nih.gov/pubmed/18847332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1359/jbmr.081002
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