Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo

Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report tha...

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Autori principali: Marcinowski, Lisa, Tanguy, Mélanie, Krmpotic, Astrid, Rädle, Bernd, Lisnić, Vanda J., Tuddenham, Lee, Chane-Woon-Ming, Béatrice, Ruzsics, Zsolt, Erhard, Florian, Benkartek, Corinna, Babic, Marina, Zimmer, Ralf, Trgovcich, Joanne, Koszinowski, Ulrich H., Jonjic, Stipan, Pfeffer, Sébastien, Dölken, Lars
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276556/
https://ncbi.nlm.nih.gov/pubmed/22346748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002510
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