Mass Homozygotes Accumulation in the NCI-60 Cancer Cell Lines As Compared to HapMap Trios, and Relation to Fragile Site Location

Runs of homozygosity (ROH) represents extended length of homozygotes on a long genomic distance. In oncology, it is known as loss of heterozygosity (LOH) if identified exclusively in cancer cell rather than in matched control cell. Studies have identified several genomic regions which show consisten...

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Bibliographic Details
Main Authors: Ruan, Xiaoyang, Kocher, Jean-Pierre A., Pommier, Yves, Liu, Hongfang, Reinhold, William C.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276511/
https://ncbi.nlm.nih.gov/pubmed/22347499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031628
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