MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGFβR2) in colon cancer cells

Although microRNA-21 (miR-21) is emerging as an oncogene and has been shown to target several tumor suppressor genes, including programmed cell death 4 (PDCD4), its precise mechanism of action on cancer stem cells (CSCs) is unclear. Herein, we report that FOLFOX-resistant HCT-116 and HT-29 cells tha...

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Библиографические подробности
Главные авторы: Yu, Yingjie, Kanwar, Shailender S., Patel, Bhaumik B., Oh, Phil-Sun, Nautiyal, Jyoti, Sarkar, Fazlul H., Majumdar, Adhip P.N.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2012
Предметы:
Biology, Genetics and Epigenetics
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276336/
https://ncbi.nlm.nih.gov/pubmed/22072622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgr246
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