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RAE1ε ligand expressed on pancreatic islets recruits NKG2D receptor-expressing cytotoxic T cells independent of T cell receptor recognition
The mechanisms by which cytotoxic T lymphocytes (CTLs) enter and are retained in non-lymphoid tissue are not well-characterized. Using a transgenic mouse expressing the NKG2D ligand retinoic acid early transcript 1ε (RAE1ε) in β-islet cells of the pancreas, we found RAE1 expression was sufficient to...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3276246/ https://ncbi.nlm.nih.gov/pubmed/22244846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.11.014 |
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