Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

Transient Receptor Potential Melastatin 3 (TRPM3) is a widely expressed calcium-permeable non-selective cation channel that is stimulated by high concentrations of nifedipine or by physiological steroids that include pregnenolone sulphate. Here we sought to identify steroids that inhibit TRPM3. Chan...

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Hauptverfasser: Majeed, Yasser, Tumova, Sarka, Green, Ben L., Seymour, Victoria A.L., Woods, Daniel M., Agarwal, Anil K., Naylor, Jacqueline, Jiang, Shannon, Picton, Helen M., Porter, Karen E., O’Regan, David J., Muraki, Katsuhiko, Fishwick, Colin W.G., Beech, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275754/
https://ncbi.nlm.nih.gov/pubmed/22000496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ceca.2011.09.005
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