Cellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus

During antiviral drug discovery, it is critical to distinguish molecules that selectively interrupt viral replication from those that reduce virus replication by adversely affecting host cell viability. In this report we investigate the selectivity of inhibitors of the host chaperone proteins cyclop...

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Autori principali: Beran, Rudolf K. F., Sharma, Ruchi, Corsa, Amoreena C., Tian, Yang, Golde, Justin, Lundgaard, Greta, Delaney, William E., Zhong, Weidong, Greenstein, Andrew E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275588/
https://ncbi.nlm.nih.gov/pubmed/22347373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030286
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