Cellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus

During antiviral drug discovery, it is critical to distinguish molecules that selectively interrupt viral replication from those that reduce virus replication by adversely affecting host cell viability. In this report we investigate the selectivity of inhibitors of the host chaperone proteins cyclop...

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Autores principales: Beran, Rudolf K. F., Sharma, Ruchi, Corsa, Amoreena C., Tian, Yang, Golde, Justin, Lundgaard, Greta, Delaney, William E., Zhong, Weidong, Greenstein, Andrew E.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275588/
https://ncbi.nlm.nih.gov/pubmed/22347373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030286
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