Cellular Growth Kinetics Distinguish a Cyclophilin Inhibitor from an HSP90 Inhibitor as a Selective Inhibitor of Hepatitis C Virus

During antiviral drug discovery, it is critical to distinguish molecules that selectively interrupt viral replication from those that reduce virus replication by adversely affecting host cell viability. In this report we investigate the selectivity of inhibitors of the host chaperone proteins cyclop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Beran, Rudolf K. F., Sharma, Ruchi, Corsa, Amoreena C., Tian, Yang, Golde, Justin, Lundgaard, Greta, Delaney, William E., Zhong, Weidong, Greenstein, Andrew E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275588/
https://ncbi.nlm.nih.gov/pubmed/22347373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030286
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