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A Distal Modular Enhancer Complex Acts to Control Pituitary- and Nervous System-Specific Expression of the LHX3 Regulatory Gene
Lin-11, Isl-1, and Mec-3 (LIM)-homeodomain (HD)-class transcription factors are critical for many aspects of mammalian organogenesis. Of these, LHX3 is essential for pituitary gland and nervous system development. Pediatric patients with mutations in coding regions of the LHX3 gene have complex synd...
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Main Authors: | , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Endocrine Society
2012
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3275162/ https://ncbi.nlm.nih.gov/pubmed/22194342 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1252 |
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