Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis in ob/ob Mice

Farnesoid X receptor (FXR) is known to play important regulatory roles in bile acid, lipid, and carbohydrate metabolism. Aged (>12 months old) Fxr(−/−) mice also develop spontaneous liver carcinomas. In this report, we used three mouse models to investigate the role of FXR deficiency in obesity....

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Autori principali: Zhang, Yanqiao, Ge, Xuemei, Heemstra, Lydia A., Chen, Wei-Dong, Xu, Jiesi, Smith, Joseph L., Ma, Huiyan, Kasim, Neda, Edwards, Peter A., Novak, Colleen M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2012
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3275160/
https://ncbi.nlm.nih.gov/pubmed/22261820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1157
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