Frequent alterations and epigenetic silencing of differentiation pathway genes in structurally rearranged liposarcomas

We explored diverse alterations contributing to liposarcomagenesis by sequencing the genome, exome, transcriptome, and cytosine methylome of a primary and recurrent dedifferentiated liposarcoma (DLPS) from distinct chemotherapy/radiotherapy-naïve patients. The liposarcoma genomes had complex structu...

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Hauptverfasser: Taylor, Barry S., DeCarolis, Penelope L., Angeles, Christina V., Brenet, Fabienne, Schultz, Nikolaus, Antonescu, Cristina R., Scandura, Joseph M., Sander, Chris, Viale, Agnes J., Socci, Nicholas D., Singer, Samuel
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274776/
https://ncbi.nlm.nih.gov/pubmed/22328974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0181
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