Probing the mechanistic role of the long α-helix in subunit L of respiratory Complex I from Escherichia coli by site-directed mutagenesis

The C-terminus of the NuoL subunit of Complex I includes a long amphipathic α-helix positioned parallel to the membrane, which has been considered to function as a piston in the proton pumping machinery. Here, we have introduced three types of mutations into the nuoL gene to test the piston-like fun...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Belevich, Galina, Knuuti, Juho, Verkhovsky, Michael I, Wikström, Mårten, Verkhovskaya, Marina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Blackwell Publishing Ltd 2011
Pynciau:
Research Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274701/
https://ncbi.nlm.nih.gov/pubmed/22060017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2011.07883.x
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