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The impact of caspase-12 on susceptibility to candidemia

Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a suscepti...

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Detalhes bibliográficos
Main Authors: Rosentul, D. C., Plantinga, T. S., Scott, W. K., Alexander, B. D., van de Geer, N. M. D., Perfect, J. R., Kullberg, B. J., Johnson, M. D., Netea, M. G.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274675/
https://ncbi.nlm.nih.gov/pubmed/21706251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10096-011-1307-x
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