Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples.

A method to detect chemically stable lesions in DNA has been developed using Exonuclease III, a double strand specific nuclease, to digest 5'-end labeled DNA. The products, when analyzed on high resolution DNA sequencing gels, reveal the sites of DNA modification. Cyclobutane pyrimidine dimers...

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Bibliografske podrobnosti
Main Authors: Royer-Pokora, B, Gordon, L K, Haseltine, W A
Format: Artigo
Jezik:Inglês
Izdano: 1981
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC327461/
https://ncbi.nlm.nih.gov/pubmed/6272211
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