Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α

BACKGROUND: Ionizing irradiation is a commonly accepted treatment modality for lung cancer patients. However, the clinical outcome is hampered by normal tissue toxicity and tumor hypoxia. Since tumors often have higher levels of active heat shock protein 90 (Hsp90) than normal tissues, targeting of...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Schilling, Daniela, Bayer, Christine, Li, Wei, Molls, Michael, Vaupel, Peter, Multhoff, Gabriele
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2012
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274537/
https://ncbi.nlm.nih.gov/pubmed/22347438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031110
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