Placental malaria is associated with attenuated CD4 T-cell responses to tuberculin PPD 12 months after BCG vaccination

BACKGROUND: Placental malaria (PM) is associated with prenatal malaise, but many PM+ infants are born without symptoms. As malaria has powerful immunomodulatory effects, we tested the hypothesis that PM predicts reduced T-cell responses to vaccine challenge. METHODS: We recruited healthy PM+ and PM-...

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Detalhes bibliográficos
Main Authors: Walther, Brigitte, Miles, David JC, Waight, Pauline, Palmero, Melba S, Ojuola, Olubukola, Touray, Ebrima S, Whittle, Hilton, van der Sande, Marianne, Crozier, Sarah, Flanagan, Katie L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274427/
https://ncbi.nlm.nih.gov/pubmed/22243970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-12-6
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