Targeting of a platinum-bound sunitinib analog to renal proximal tubular cells

BACKGROUND: Activated proximal tubular cells play an important role in renal fibrosis. We investigated whether sunitinib and a kidney-targeted conjugate of sunitinib were capable of attenuating fibrogenic events in tubulointerstitial fibrosis. METHODS: A kidney-targeted conjugate was prepared by lin...

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Detalles Bibliográficos
Autores principales: Dolman, ME (Emmy) M, Harmsen, Stefan, Pieters, Ebel HE, Sparidans, Rolf W, Lacombe, Marie, Szokol, Bálint, Őrfi, László, Kéri, György, Storm, Gert, Hennink, Wim E, Kok, Robbert J
Formato: Artigo
Lenguaje:Inglês
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3273977/
https://ncbi.nlm.nih.gov/pubmed/22334775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S26485
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