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Cre-mediated recombination can induce apoptosis in vivo by activating the p53 DNA damage-induced pathway
Cre-mediated apoptosis has been observed in many contexts in mice expressing Cre-recombinase, and can confound the analysis of genetically engineered conditional mutant or transgenic alleles. Several mechanisms have been proposed to explain this phenomenon. We find that the degree of apoptosis induc...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2012
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3273649/ https://ncbi.nlm.nih.gov/pubmed/21913308 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/dvg.20799 |
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