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Constitutive activation of the ETS-1-miR-222 circuitry in metastatic melanoma
MicroRNAs-221 and -222 are highly upregulated in several solid tumors, including melanomas. We demonstrate that the proto-oncogene ETS-1, involved in the pathogenesis of cancers of different origin, is a transcriptional regulator of miR-222 by direct binding to its promoter region. Differently from...
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Main Authors: | , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Blackwell Publishing Ltd
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3272348/ https://ncbi.nlm.nih.gov/pubmed/21711453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1755-148X.2011.00881.x |
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