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Benzo[a]pyrene, Aflatoxine B(1) and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology

Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as a fingerprint of aflatoxin B(1) exposure. Like...

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Detalhes bibliográficos
Main Authors: Paget, Vincent, Lechevrel, Mathilde, André, Véronique, Le Goff, Jérémie, Pottier, Didier, Billet, Sylvain, Garçon, Guillaume, Shirali, Pirouz, Sichel, François
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3272023/
https://ncbi.nlm.nih.gov/pubmed/22319594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0030921
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