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Mechanical compression drives cancer cells toward invasive phenotype

Uncontrolled growth in a confined space generates mechanical compressive stress within tumors, but little is known about how such stress affects tumor cell behavior. Here we show that compressive stress stimulates migration of mammary carcinoma cells. The enhanced migration is accomplished by a subs...

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Detalhes bibliográficos
Main Authors: Tse, Janet M., Cheng, Gang, Tyrrell, James A., Wilcox-Adelman, Sarah A., Boucher, Yves, Jain, Rakesh K., Munn, Lance L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271885/
https://ncbi.nlm.nih.gov/pubmed/22203958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118910109
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