Adjudin disrupts spermatogenesis via the action of some unlikely partners: Eps8, Arp2/3 complex, drebrin E, PAR6 and 14-3-3

Adjudin, 1-(2,4-dichlorobenzyl)-1H-indazole-3-carbohydrazide (formerly called AF-2364), is a potent analog of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazole-3-carboxylic acid] known to disrupt germ cell adhesion, most notably elongating and elongated spermatids, in the seminiferous epithelium of adu...

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Главные авторы: Cheng, C Yan, Lie, Pearl PY, Wong, Elissa WP, Mruk, Dolores D, Silvestrini, Bruno
Формат: Artigo
Язык:Inglês
Опубликовано: Landes Bioscience 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271640/
https://ncbi.nlm.nih.gov/pubmed/22332112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/spmg.1.4.18393
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