Death Receptors 4 and 5 Activate Nox1 NADPH Oxidase through Riboflavin Kinase to Induce Reactive Oxygen Species-mediated Apoptotic Cell Death

Stimulation of the proapoptotic tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors, death receptors 4 (DR4) and 5 (DR5), conventionally induces caspase-dependent apoptosis in tumor cells. Here we report that stimulation of DR4 and/or DR5 by the agonistic protein KD548-Fc...

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Autors principals: Park, Kyung-Jin, Lee, Chang-Han, Kim, Aeyung, Jeong, Ki Jun, Kim, Chul-Ho, Kim, Yong-Sung
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270986/
https://ncbi.nlm.nih.gov/pubmed/22158615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.309021
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