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Substrate Specificity of Bacterial Prolyl-tRNA Synthetase Editing Domain Is Controlled by a Tunable Hydrophobic Pocket

Aminoacyl-tRNA synthetases catalyze the covalent attachment of amino acids onto their cognate tRNAs. High fidelity in this reaction is crucial to the accurate decoding of genetic information and is ensured, in part, by proofreading of the newly synthesized aminoacyl-tRNAs. Prolyl-tRNA synthetases (P...

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Hlavní autoři: Kumar, Sandeep, Das, Mom, Hadad, Christopher M., Musier-Forsyth, Karin
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270972/
https://ncbi.nlm.nih.gov/pubmed/22128149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313619
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