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Catalytic Mechanism of Rhomboid Protease GlpG Probed by 3,4-Dichloroisocoumarin and Diisopropyl Fluorophosphonate

Rhomboid proteases have many important biological functions. Unlike soluble serine proteases such as chymotrypsin, the active site of rhomboid protease, which contains a Ser-His catalytic dyad, is submerged in the membrane and surrounded by membrane-spanning helices. Previous crystallographic analys...

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Sonraí Bibleagrafaíochta
Main Authors: Xue, Yi, Ha, Ya
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270966/
https://ncbi.nlm.nih.gov/pubmed/22130671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.310482
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