Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte

Inotropy and lusitropy in the ventricular myocyte can be efficiently induced by activation of β1-, but not β2-, adrenoceptors (ARs). Compartmentation of β2-AR-derived cAMP-dependent signalling underlies this functional discrepancy. Here we investigate the mechanism by which caveolae (specialised sar...

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Autors principals: MacDougall, David A., Agarwal, Shailesh R., Stopford, Elizabeth A., Chu, Hongjin, Collins, Jennifer A., Longster, Anna L., Colyer, John, Harvey, Robert D., Calaghan, Sarah
Format: Artigo
Idioma:Inglês
Publicat: Academic Press 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270222/
https://ncbi.nlm.nih.gov/pubmed/21740911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.06.014
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