Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

Pathogenic mutations in APP, PSEN1, PSEN2, MAPT and GRN have previously been linked to familial early onset forms of dementia. Mutation screening in these genes has been performed in either very small series or in single families with late onset AD (LOAD). Similarly, studies in single families have...

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Main Authors: Cruchaga, Carlos, Chakraverty, Sumitra, Mayo, Kevin, Vallania, Francesco L. M., Mitra, Robi D., Faber, Kelley, Williamson, Jennifer, Bird, Tom, Diaz-Arrastia, Ramon, Foroud, Tatiana M., Boeve, Bradley F., Graff-Radford, Neill R., St. Jean, Pamela, Lawson, Michael, Ehm, Margaret G., Mayeux, Richard, Goate, Alison M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3270040/
https://ncbi.nlm.nih.gov/pubmed/22312439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0031039
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