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Microarray Analysis Reveals Age-related Differences in Gene Expression During the Development of Osteoarthritis in Mice

OBJECTIVE: To better understand the contribution of age to the development of osteoarthritis (OA). METHODS: Surgical destabilization of the medial meniscus (DMM) was used to model OA in 12 week-old and 12 month-old male C57/BL6 mice. OA severity was evaluated histologically. RNA used for microarrays...

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Autors principals: Loeser, Richard F., Olex, Amy, McNulty, Margaret A., Carlson, Cathy S., Callahan, Michael, Ferguson, Cristin, Chou, Jeff, Leng, Xiaoyan, Fetrow, Jacquelyn S.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269534/
https://ncbi.nlm.nih.gov/pubmed/21972019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33388
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