Evidence for a role of anti-ADAMTS13 autoantibodies despite normal ADAMTS13 activity in recurrent thrombotic thrombocytopenic purpura

BACKGROUND: Severe ADAMTS13 deficiency is a critical component of the pathogenesis of idiopathic thrombotic thrombocytopenic purpura but is found only in about 60% of patients clinically diagnosed with this disease. DESIGN AND METHODS: Over a period of 8 years and six episodes of thrombotic thromboc...

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Detalhes bibliográficos
Main Authors: Froehlich-Zahnd, Rahel, George, James N., Vesely, Sara K., Terrell, Deirdra R., Aboulfatova, Khatira, Dong, Jing-Fei, Luken, Brenda M., Voorberg, Jan, Budde, Ulrich, Sulzer, Irmela, Lämmle, Bernhard, Kremer Hovinga, Johanna A.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2012
Assuntos:
Original Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269492/
https://ncbi.nlm.nih.gov/pubmed/21993669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2011.051433
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