Structural insights into the allosteric effects of 4EBP1 on the eukaryotic translation initiation factor eIF4E

The eukaryotic translation initiation factor eIF4E plays key roles in cap dependent translation and mRNA export. These functions rely on binding the 7-methylguanosine moiety (5′cap) to the 5′-end of all mRNAs. eIF4E is regulated by proteins such as eIF4G and eIF4E binding proteins (4EBPs) that bind...

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Main Authors: Siddiqui, Nadeem, Tempel, Wolfram, Nedyalkova, Lucy, Volpon, Laurent, Wernimont, Amy K., Osborne, Michael J., Park, Hee-Won, Borden, Katherine L.B.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3269305/
https://ncbi.nlm.nih.gov/pubmed/22178476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.12.002
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